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the conserved rieske oxygenase daf

The Sterol-C7 desaturase from the ciliate

A Rieske oxygenase was also identified; this type of enzyme, with sterol C7(8)-desaturase activity, was observed only in animals, called Neverland in insects and DAF-36 in nematodes. They perform the conversion of cholesterol into 7-dehydrocholesterol, first step in the synthesis of the essential hormones ecdysteroids and dafachronic acids.

A Novel 3-Hydroxysteroid Dehydrogenase That Regulates

The conserved Rieske oxygenase DAF-36/Neverland is a novel cholesterol metabolizing enzyme. (2003). The enzymes, regulation, and genetics of bile acid synthesis. A Rieske oxygenase/epoxide hydrolase-catalysed reaction Nov 26, 2018 · Yoshiyama-Yanagawa, T. et al. The conserved Rieske oxygenase DAF-36/Neverland is a novel cholesterol-metabolizing enzyme. J.

A Steroid ReceptorMicroRNA Switch Regulates Life Span in

Dec 14, 2012 · However, by L4 and day 1 of adulthood (D1), the hormone biosynthetic gene daf-36 /Rieske-oxygenase was significantly up-regulated in glp-1 (Fig. 1A and fig. S1D, as well as supplementary materials BRENDA - 1.3.1.21:7-dehydrocholesterol reductaseMar 01, 2021 · The Rieske oxygenase DAF-36 functions as a cholesterol 7-desaturase in steroidogenic pathways governing longevity Aging Cell 10 879-884 2011 The conserved Rieske oxygenase DAF-36/Neverland is a novel cholesterol-metabolizing enzyme J. Biol. Chem. 286 25756-25762 2011

CDD Conserved Protein Domain Family:Rieske

Jan 08, 2020 · cl00938 (PSSM ID:382297):Conserved Protein Domain Family Rieske, Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes Carnitine metabolism to trimethylamine by an unusual Mar 18, 2014 · Metabolism of l-carnitine, a compound abundant in human diet, to trimethylamine by human microbiota has been shown to promote atherosclerosis and subsequent development of heart disease. However, the underpinning molecular and biochemical mechanisms remain unknown. In this study, we reveal that a previously unidentified Rieske-type protein is

EAK proteins:novel conserved regulators of C. elegans

The conserved protein lifespan KRI-1 is required for DAF-16/FoxO nuclear transloca- tion in animals lacking a germline but largely dispensable DAF-16/FoxO is required for C. elegans lifespan for DAF-16/FoxO nuclear localization in animals with modulation by IIS and the germline [1, 2], as well as in reduced IIS [29]. Frontiers Eion, Purification, Refolding, and Oct 21, 2020 · The reaction can be catalyzed by the evolutionarily conserved Rieske-domain oxygenase neverland (NVD), which contains a Rieske [2Fe2S] cluster binding domain to function as an electron acceptor and electron transfer, and a highly conserved non-heme iron-binding center as a catalytic domain (Yoshiyama et al., 2006).

Hiroshi Kataoka -

6) Yoshiyama-Yanagawa, T. et al. (2011) The conserved Rieske oxygenase DAF-36/Neverland is a novel cholesterol metabolizing enzyme. J. Biol. Chem., 286, 25756-25762. Other Activities:Japan Society for Bioscience, Biotechnology, and Agrochemistry The Japan Society for Comparative Endocrinology The Japanese Peptide Society:Future Plan KEGG ENZYME:1.14.19.21Jan 14, 2019 · The conserved Rieske oxygenase DAF-36/Neverland is a novel cholesterol-metabolizing enzyme.

MetaCyc EC 1.14.19.21

"The Sterol-C7 desaturase from the ciliate Tetrahymena thermophila is a Rieske Oxygenase, which is highly conserved in animals." Mol Biol Evol 30(7);1630-43. PMID:23603937 Sterol-C7 Desaturase from the Ciliate Tetrahymena Apr 19, 2013 · This work reports the identification of a Rieske [2Fe-2S] oxygenase, belonging to the Nvd/DAF-36 family of proteins, as the sterol C7(8)-desaturase of T. thermophila. Furthermore, we provide strong phylogenetic evidence showing that this family of proteins is evolutionarily conserved not only in animals but also in ciliates of the clade

Structure and Function of Aromatic-Ring Hydroxylating

Sep 23, 2013 · Yoshiyama-Yanagawa T, Enya S, Shimada-Niwa Y, Yaguchi S, Haramoto Y, Matsuya T, Shiomi K, Sasakura Y, Takahashi S, Asashima M, Kataoka H, Niwa R (2011) The conserved Rieske oxygenase DAF-36/Neverland is a novel cholesterol-metabolizing enzyme. J Biol Chem 286:2575625762 PubMed CrossRef Google Scholar The Sterol-C7 Desaturase from the Ciliate Tetrahymena The Sterol-C7 Desaturase from the Ciliate Tetrahymena thermophila Is a Rieske Oxygenase, Which Is Highly Conserved in Animals Molecular Biology and Evolution , Jul 2013 Sebastián R. Najle , Alejandro D. Nusblat , Clara B. Nudel , Antonio D. Uttaro

Thermophilic bacteria are potential sources of novel

Jan 04, 2017 · Rieske non-heme iron oxygenases, which have a Rieske-type [2Fe2S] cluster and a non-heme catalytic iron center, are an important family of oxidoreductases involved mainly in regio- and stereoselective transformation of a wide array of aromatic hydrocarbons. Though present in all domains of life, the most widely studied Rieske non-heme iron oxygenases are daf-36 - Cholesterol 7-desaturase - Caenorhabditis elegans Oct 01, 2003 · Catalyzes the production of 7-dehydrocholesterol (7-DHC) by the desaturation of the C7-C8 single bond of cholesterol. This reaction is the first step in the synthesis of the steroid hormone Delta(7)-dafachronic acid. Dafachronic acids bind directly to the nuclear hormone receptor (NHR) daf-12, suppressing dauer formation and inducing reproductive growth.

The conserved Rieske oxygenase DAF-36/Neverland is a

J Biol Chem July 22, 2011; 286 (29):25756-62. The conserved Rieske oxygenase DAF-36/Neverland is a novel cholesterol-metabolizing enzyme.

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